Based on the analysis of saltwater intrusion in the Yangtze Estuary and its development trend, influencing factors of saltwater intrusion into water sources area and is disaster response measures, etc. , the framework system and related factors or indicators of the saltwater disaster response plan in the water source area Yangtze Estuary of were studied. The design schemes of the plan organization and responsibility, monitoring, forecasting, early warning, emergency response and support system were put forward respectively.