This paper constructs a game model of inter- regional wader pollution prevention and control of three adjacent regions an a game model of regional water pollution prevention and control for government regulation and sewage enterprises，It analyses the optimal strategies of the stakeholders of transboundary water pollution and contro by using game theory method.Then it makes the following suggestions:establishing total control and allocation mechanism of regional wader pollutant，selling up public participation mechanism of transboundary water pollution and control system and long-germ environmental and economic policies.