The revolutionary change of Marxism philosophy is developed in the practice of constant struggle. The issue of “material interests” is the harassing problem to Marx because his early idealism thought keeps conflict with objective reality. It is the period of 1844 Economic Philosophy Manuscript (called Manuscript) that Marx’ philosophical thought undergoes a revolutionary change on the basis of the study of economics. In the Manuscript, Marx introduces human practice to philosophical criticism and realizes the transformation of philosophy from conceptual ontology to practical ontology. Marx holds that material production plays decisive role in and thus makes revolutionary transformation on historical idealism by means of historical materialism. Based on the new interpretation of alienated labor, Marx scientifically predicts the inevitability of the realization of the proletariat’s communism ideals. Therefore, in the new era, to keep on developing Marxism, it is necessary to understand the internal logic of the transformation of Marx’s philosophical thought.