General Secretary Xi Jinping put forward a series of new ideas and new strategies for ideological and political education in colleges and universities, which respectively answered, in ontological, axiological and methodological dimensions, the content system of “what”, the internal requirements of “why” and the way of “how to do”. Learning and comprehending the rich connotation of this innovative discourse and its open and innovative scientific system, bearing in mind the responsibility of the mission, establishing morality and cultivating people’s value orientation, materialistic and dialectical thinking methods and other theoretical characters will help us grasp the fundamental problems of “what kind of people to cultivate, how to cultivate and for whom to cultivate” in the ideological and political work of colleges and universities, which is of great practical significance to promote the innovation and development of ideological and political education of colleges and universities in the new era. It is necessary to promote the theoretical and practical innovation and development of ideological and political education in colleges and universities in the new era in the aspects of theoretical guidance and research deepening, development concept and value guidance, teaching and scientific research and personnel training.