The outbreak of the COVID19 in 2020 is a major public health emergency of global concern. Xi Jinping, the general secretary of CCP, pointed out that it is necessary to strengthen the guidance of public opinion and create an atmosphere of strong confidence, warmth, and gathering of public opinion. Based on the national level, this study summarizes the news strategies during the epidemic into three typical strategic frameworks——constructing a big country image (to show strong confidence), building a community culture (to warm people), and establishing a fair mechanism (to gather people), and then conducts empirical research. The research found that people’s responses to the mainstream news of the three typical strategies tend to be more positive, with higher recognition and confidence. Personnel from state agencies and enterprises, people with stable incomes, and middleaged and young people aged 26 to 45 have stronger confidence in the country. And it was also found that in this pandemic prevention and control, “crossborder integration” is a very important successful experience for our country. This research has laid a theoretical foundation for the guidance of public opinion, and the research conclusions can provide reference for the government’s specific operation of public opinion guidance in public management.