To explore the application method of MICP in the actual project, the MICP grouting pipe is used to reinforce the soil in this study. That is to insert the grouting pipe into the soil through holes of different densities, then penetrate the bacteria fluid and the cementing fluid into the soil through the holes on the grouting pipe, and at last, the cemented sand column can be formed in the soil. By comparing the reinforcement effect of contrast experiments, the results show that this grouting method can be used to form a complete and high strength cemented sand column and the strength of each layer is relatively balanced.