According to the characteristics of impact assessment of river regulation projects, an impact assessment model forriver regulation projects is proposed bycombining qualitative and quantitative analyses. The evaluation index system is established by taking four aspects into consideration, including influences of economic development, social development, social environment and rational utilization of natural resources. The entropy combination weight method is used to determine the weights of various indices. Taking the river regulation project of Puyang River in the Yellow River as the research object, the impact degree of the project is analyzed, and the calculated results by the proposed model show that the impact degree is grade Ⅱ(good).