The evaluation of water ecological effect can provide scientific decision-making basis for the rational development of coastal reclamation areas. By analyzing the influencing factors of water ecological effect, the comprehensive evaluation system and model for the water ecological effect including social economic subsystem and water ecological subsystem are investigated and established. The analytic hierarchy process and the entropy weight method are used to synthesize weights from subjective and objective perspectives. Dongtai City, Sheyang County and DafengDistrict in the coastal reclamation area are taken as typical examples to conduct empirical analysis ofevaluation of water ecological effect, and the evaluated results of water ecological effect are analyzed. Some suggestions are put forward as follows: full play of the advantages of natural resources and water ecological environment, optimization of the industrial layout, and improvement of the water ecological effect.