With the frequent flooding and pollution of the water environment in China, the comprehensive treatment of the water environment in specific watersheds is a matter of urgency. Generally, such projects have huge quantities, complex and cumbersome contents, and are easy to be concerned by all sectors of society, so it is particularly important to take whole life cycle control. This paper analyzes the case of Maozhou River Basin Integrated Water Environment Treatment Project, takes different measures for different stages of the whole life cycle, and summarizes a set of advanced water environment treatment experience, including the pioneering treatment mode, the “five in one” water-based treatment concept of water resources, water security, water environment, water ecology and water culture, advanced water control technology, intelligent water affairs and multi-party coordinated governance pattern, which can provide reference for the national comprehensive treatment project of water environment.