A batch of experimental research was conducted to analyze the curing mechanism and influencing factors of arsenic(As)from aqueous solutions by iron-oxide coated sand(IOCS)in this paper. The results showed that: the removal efficiency of IOCS on As increased with the rise of Fe concentration on the surface of IOCS, adsorption and solid-liquid distribution coefficients increased with the increase of reaction time. The pseudo-second-order model can better describe the adsorption behavior of As on the surface of the IOCS. The isothermal adsorption test results showed that the fitting effects of Freundlich model were better and the index 1/n decreased with the increasing with the Fe concentration on the surface of IOCS, which indicated that IOCS treated with high concentration of iron salt had stronger constraint for arsenic. In addition, different concentration of IOCS on the adsorption capacity of As(Ⅲ)and As(Ⅴ)increased with the rise of reaction temperature and, while the temperature had a more significant effect on As(Ⅲ)than on As(Ⅴ). The IOCS treated with different iron salt under different pH values had significantly better capacity of adsorption removal of As(Ⅲ), As(Ⅴ)than the untreated sandy media, but both showed the tendency that the adsorption capacity decreased with the increase of pH.