In order to solve the ecological, functional and spatial problems of rivers and lakes in China, a spatial management and control framework of rivers and lakes based on zoning and classification function is proposed. Taking Jiangsu Province as the research object, based on the four river water systems in the province, combined with the natural geography, water resources, ecological conditions and other conditions of the province, the natural geography, water resources, administrative water system, flood control and waterlogging control, soil and water conservation and water resources protection are divided. Based on the synergetic theory, the spatial fusion of the divisions is carried out, and the final zoning scheme is obtained. Then the primary and secondary functions of rivers and lakes in the division are analyzed and summarized, and the control scope of each division is delimited according to the existing scope regulations and red line requirements.