In view of the large-scale use of organophosphorus pesticide chlorpyrifos in the farmland system, the residues of chlorpyrifos in the farmland system increased significantly. However, the traditional microbial method for the degradation of chlorpyrifos had some shortcomings, such as low degradation efficiency and long action time. So the degradation of chlorpyrifos by microbial physicochemical coupling method was studied. Based on the review of the operation effect and action mechanism of the degradation of chlorpyrifos by microbial coupled electrochemistry, zero valent iron, plant and photocatalytic, it was described that the degradation of chlorpyrifos by microbial physicochemical coupling method has the advantages of high degradation efficiency, short action time and effective enrichment of functional bacteria. It provided a scientific basis for optimizing the remediation technology of chlorpyrifos pollution and improving the degradation efficiency of chlorpyrifos.