In order to implement the inevitable requirement and one of the important tasks of the “sixteen character” water treatment thought—the evaluation of intensive and safe utilization of water resources, under the guidance of the policy of water saving priority and ecological priority, the evaluation index system of intensive and safe utilization of water resources was discussed. After that, AHP-CRITIC comprehensive weighting and the symmetrical cross-entropy multi-attribute ranking method were adopted, and the evaluation model of intensive and safe utilization of water resources was established. The research involve 31 provincial administrative regions(excluding Hong Kong, Macao and Taiwan)in China in 2019 the results indicate that the intensive and safe utilization of water resources in the 31 provincial administrative regions is generally at a medium level, and the level of the intensive and safe utilization of water resources has a huge room for progress. In addition, the relationship between the intensive utilization of water resources and the safe utilization of water resources is heterogeneous. There is a great disparity in the level of intensive utilization and safe utilization in some provincial administrative regions such as Beijing, Tianjin and Xinjiang, which needs to be optimized. Therefore, it is one of the most important strategies for China to implement the new development philosophy and promote the level of intensive and safe utilization of water resources.