The effect of a sialic mineral admixture on the sulfate attack of cement-based material with limestone at low temperature was studied based on analysis of the visual appearance and strength changes of specimens, and erosion phases through erosion experiments. The results show that, with an increase of the content of the sialic mineral admixture, the integrity of the Portland cement specimens with limestone powder improved, and the strength loss ratios of the specimens decreased. When 15% and 30% of sialic mineral admixtures were added, the mineral powder had a greater effect in increasing the resistance to sulfate attack of the cement-based material with limestone than fly ash with the same content. Furthermore, the sialic mineral admixture could defer the sulfate attack of Portland cement with limestone powder at low temperature, and restrain the formation of thaumasite.