At present, industrial parks in Yangtze River Delta Region are facing multiple restrictions on water resources, water environment, water ecology and carbon emissions. The efficient utilization of water resources in the industrial parks is an important support for the high-quality development of the Yangtze River Delta Region, with the sewage resource utilization as a key way to achieve the goal. Based on the relevant research, practice and policy as well as the combination of the principles of comprehensive planning and systematic optimization, a strategy for the efficient utilization of water resources in the industrial parks was proposed with the five-level treatment and five-level reuse system as the core. Based on the “double carbon” strategy, a new idea for the efficient and low-carbon utilization of water resources in the industrial parks coupled with the sewage reuse, resource recovery, energy conservation and multi-energy complementary was proposed, which could promote the collaborative optimization of water conservation, pollution reduction and carbon reduction. It can also be found that the utilization of water resources in industrial parks in Yangtze River Delta Region should develop towards a low-carbon, regional, integrated and intelligent mode in the future.