In order to study the hydrodynamic response characteristics and anti-rocking measures of large floating bodies in the waters of Maldives, a numerical model of hydrodynamic response of floating tanks is established based on the three-dimensional potential flow theory and the rigid-body motion equation, the hydrodynamic response characteristics of floating tanks with different aspect ratios are analyzed, the influence of anti-shake plate layout and type on the anti-rocking effect of floating tanks is discussed, and a better layout scheme of anti-shake plates is given on this basis. The results show that the rectangular floating box with an aspect ratio of 2∶1 has a relatively stable motion response in each wave. The width of the anti-shake plate has an obvious control effect on the floating box, and when the anti-shake plate is installed at the same time on the floating box and the back wave surface, the anti-rocking effect is significantly affected by the installation height. For the double-layer open-hole anti-rocking plate on the facing side, when the opening of the upper anti-shake plate is 40%, the control over the rocking of the floating box is better, and the rollover of the floating box can be reduced by 16.9% under the limit sea state. This study recommends the single-sided double-layer anti-rocking plate layout form with the opening of the upper layer. The installation of the anti-shake plate has little effect on the strength of the floating structure under the action of waves, and attention should be paid to the connection strength of the anti-shake plate and the shell.