Based on the multi-regional input and output table, the water, energy, and food (WEF) resource flow between Guangdong Province and other provinces/autonomous regions/cities in China was calculated, and the amount of risk transferred through WEF resource flow between these provinces/autonomous regions/cities was innovatively quantified. Moreover, the value of risk transfer was explored.The results show that:in the inter-provincial WEF resource trade, the net inflow of embodied water to Guangdong Province is 11.706 billion cubic meters; the net inflow of embodied energy is 2.80×109GJ, and the net inflow of embodied food is 16.229 3 million tons. Most regions have a net inflow of WEF resources to Guangdong Province, with Guangxi Zhuang Autonomous Region, Henan, Anhui, and Hunan provinces exhibiting the highest inflow values.The influence coefficient and induction coefficient of WEF resources in Guangdong Province are low, and the driving and influence effect on other provinces/autonomous regions/cities in the national WEF resource trade is not strong. In addition, the induction ability of resource consumption changes in other provinces/autonomous regions/cities is weak. The risk transfer value of WEF resource flows exhibits an asymmetrical pattern between input and output regions. For most regions,the risk transfer value of WEF resource flow into Guangdong Province is high. On the basis of alleviating the risk of WEF resources in Guangdong Province, the risk in these regions has not significantly improved, especially in Hainan Province, Tianjin City, Shanghai City, Henan Province, and Gansu Province.The risk transfer value of Yunnan Province, Beijing City, Shanxi Province, and Zhejiang Province is relatively low,and the WEF resource risk caused by the resource input of Guangdong Province is relatively large.