In order to consider the importance of the economic benefit,virtual water consumption,fairness difference of water use per person,and nutrition factors in the regional planning of production of agricultural and livestock products,the optimized allocation problem of water resources based on the virtual water and nutrition was studied. A multi-objective optimization model with the maximum economic benefit,the minimum fairness difference of water use per person,and the minimum virtual water consumption,meeting the constraints of nutrition factors,was established. The model was solved using the variable fuzzy decision-making theory and an optimal scheme for production of each kind of agricultural and livestock product was obtained. The model was run based on data from the Shiyang River Basin,and the results show that the scheme obtained from the model is the optimal scheme.