Based on the monitoring data of water quality and quantity in major rivers around Taihu Lake and the monitoring data of the water quality in Taihu Lake timing from 2007 to 2017, four major pollutant indicators, including potassium permanganate, ammonia nitrogen, total nitrogen and total phosphorus are used to explore the pollutant load spatio-temporal distribution of different regions around Taihu lake, and further to evaluate the influences of the pollutant loads of the major rivers around the lake on spatio-temporal changes of the water quality in Taihu Lake. By analyzing the water quantity of the major rivers around Tahihu Lake and incorporating the long- term changes of the pollutant loads of the major rivers, the contribution of water quantity and quality in the major rivers to the pollutant loads of the Taihu Lake is investigated in a quantitive way so as to determine the impacts of the pollutant loads of the major rivers around the lake on the water quality in Taihu Lake. The results show that the major rivers around Taihu Lake have been effectively managed in recent years, indicating that controlling the pollutants of the rivers around Taihu Lake is an important approach to ease and control the input of pollution load into Taihu Lake, thus providing a reference for the formulation and implementation of the total discharge limit of the pollution load of the rivers into Taihu Lake.