The water resources are the important material basis to support the sustainable development of social economy, and their sustainable utilization is the prerequisite to harmonious development of the water resources and the social economy. Based on the water resources-social economy complex system, an index system for the coupling coordination development of water resources and social economy is established. The entire-array-polygon evaluation method is employed to measure the comprehensive development index of the water resource system and the social economy system in Nanjing City from 2007 to 2014, and the coupling coordination degree model is used to calculate the coupling coordination degree between the two systems. The results show that Nanjing City transits from the severe recession state to the reluctant coordination development one. The entire-array-polygon evaluation method is used to analyze the dynamic development tendencies of water resource system and social economy system, and some rational suggestions are put forward with respect to the problems during their development processes.