The open development is of great significance for improving the comprehensive benefits of the Middle Route Project of South-to-North Water Diversion. Since its operation, the Middle Route Project of South-to-North Water Diversion has actively learned from the experience of construction and operation management of worldwide large-scale water control projects, actively carried out regional cooperation, opened the authority of management of construction, operation and maintenance, and cooperated with the original urban water system to boost the construction of urban ecological water system, etc. These measures have played a positive role in giving full play to its comprehensive benefits. However, on the whole, the opening of the Middle Route Project of South-to-North Water Diversion is still at its initial stage. There are the following deficiencies: insufficient opening initiative, relatively few opening fields, relatively weak opening strength, and short going global of spirit, technology and experience of South-to-North Water Diversion Project. The concept of open development, active opening, and two-way, fair and full opening should be followed, and every effort is made to enhance the comprehensive benefits of the Middle Route Project of South-to-North Water Diversion, so that the purpose of “Work in the contemporary and benefit in the future” of the great South-to-North Water Diversion Project is truly achieved.