Based on TM/Landsat8 OLI image data and land use data, the ecological environment quality index and distribution index were used to analyze the production-living-ecological space land use and eco-environment effect in Qianzhong Water Conservancy Hub Project area from 2000 to 2020. The response characteristics of land use change and ecological environment effect to topography and landform were also analyzed. The results show that from 2000 to 2020, the land use in the area has the overall characteristics that the ecological land is the most, followed by production land and living land. The area of ecological land first decreases and then increases. The area of production land has a decrease-increase-decrease trend while the area of living land shows a trend of continuous increase. The conversion among grassland ecological land, forest ecological land and agricultural production land is higher than other types of conversion, and the grassland ecological land area has the highest conversion. The ecological environment quality is fluctuated in the project area. The ecological environment quality in the eastern and western parts of the project area is generally better than that in the central part of the project area. The ecological environment quality in the areas with elevation greater than 1 700 m and slope greater than 15° and the eastern and southern slopes is better, while the ecological environment quality in the low altitude areas is gradually improving. The eco-environmental quality of non-karst and pure karst areas is better than that of sub-karst areas, but the eco-environmental quality of non-karst and pure karst areas shows a declining trend.