Based on the Caochi landslide mass in the upstream of the Qingyukou Reservoir, the finite difference method for parameter optimization design of anti-slide piles with pre-stressed anchor cable was used to analyze the deformation and force distribution of the landslide under different states. The results show that the pile position has a great influence on the stability of the landslide mass, and the safety factor of the landslide stability increases and then decreases with the distance between the pile position and the slope toe. Under the same pile position, there exists a critical length of the anchorage section of the anti-sliding pile, which is 30 m. The influence of the pile spacing on the stability of landslide mass is greater than the section size of anti-slide pile. In the range of 26° to 35°, the angle of anchor cable has little effect on the landslide stability. Through comprehensive analysis, it is suggested that the section size, pile spacing and anchor cable angle of the anti-slide pile should be 2.5 m×3.5 m, 7 m and 27°, respectively.