In order to explore a new method for solving the problem of optimal operation of hydropower station, a new swarm intelligent optimization algorithm, i.e., wolf pack search algorithm, and its application to optimal operation of hydropower station were studied. The siege algorithm of the wolf pack search algorithm was improved. Design and solving steps of the wolf pack search algorithm for solving the problem in optimal operation of hydropower station were proposed. Based on the simulation test and analysis of the example of optimal operation of hydropower station, the effective range of the step on the raid of the wolf pack search algorithm was proposed. Simulation results show that the wolf pack search algorithm is new effective method for optimizing the operation of hydropower station.