The formation and development of high-resolution sequence stratigraphy and its application in the comparison of Quaternary and fluvial facies strata are reviewed. Potential future applications of high-resolution sequence stratigraphy in division and comparison of the Quaternary aquifer are analyzed. Using the high-resolution sequence stratigraphy theory, the relationship between the base level cycle, accommodation, and stratum response can be analyzed, the isochronal stratigraphic framework of fluvial facies can be established, and the distribution characteristics of different microfacies and spatio-temporal distribution of a fluvial sand body can be found, which is conducive to the reasonable division and comparison of the loose Quaternary aquifer(group)of fluvial facies in plain regions. In the application, quantitative study should be strengthened. On the basis of defining the time range, all levels of base level cycles can be identified and divided on specification. Special attention should be paid to distinguishing the auto-cycle and allo-cycle of the fluvial facies stratum based on the sedimentary dynamics analysis of geological process-response.