In order to solve the anti-sliding stability problem of the high-fill revetment along the Yangzte River, the vibro-replacement method was used to treat the deep overburden foundation of high-fill revetment. The results show that the design of the range of vibration stone columns, pile spacing, and pile length should be matched with the terrain and geological conditions. The vibro-substitution method combined with other foundation treatment methods can achieve better treatment effects. Through vibro-replacement, the anti-sliding stability of the revetment can meet the requirements of specifications. Using the vibration stone column to replace the soft foundation replacement to form a composite foundation, the problems of sand liquefaction, bearing capacity, and shear strength of the foundation can be solved effectively.