Based on the data of MODIS-NDVI, air temperature, precipitation and atmospheric circulation index from 2000 to 2019, the dynamic evolution characteristics of vegetation in Liaoning Province under the influence of climate and human activities were discussed by using trend analysis, correlation analysis, path analysis and residual analysis. Combined with the superposition of trend coefficient and Hurst index, the future change trend of vegetation was analyzed. The results show that the average annual NDVI increased at a rate of 0.004/a in Liaoning Province, and the overall vegetation status was good. Spatially, the vegetation coverage in Liaoning Province was mainly improved, with slight degradation in Liaoyang and Shenyang citys. The response of vegetation to precipitation in Liaoning Province was higher than that of air temperature, and the impact of human activities on vegetation in Liaoning Province changed from negative to positive from 2000 to 2019. In the reverse continuous change of NDVI in Liaoning Province, the degraded area accounts for 55.24% of the total area, which shows the spatial distribution of NDVI scattered in the whole region. In the future, the efforts of vegetation conservation and returning farmland to forest should be strengthened. Keywords: human activity; vegetation variation; NDVI; hydrothermal condition; residual analysis; Hurst index; Liaoning Province 〖FL