After analyzing the cause of water resources vulnerability of Wuhan City Circle, we developed a water resources vulnerability evaluation index system based on the DPSIR model. We obtained weights of factors using entropy value method, and made an evaluation of water resource vulnerability of Wuhan City Circle with the fuzzy comprehensive evaluation method. We also compared the water resources vulnerability of Wuhan City Circle with that of Hubei province. The result indicates that water resources of Wuhan City Circle are more vulnerable and there are more insecurity factors. The spatial distribution of water resources vulnerability of Wuhan City Circle is different with the trend of increasing from southeast to northwest. We suggest that we should prevent and control water pollution, maintain and improve water conservancy facilities, save water and improve water use efficiency, and strengthen water resources planning and management.