Typical years in the Ganjiang River Basin were identified according to the standardized precipitation index (SPI). Based on the soil and water assessment tool (SWAT) model, this study analyzed the spatial and temporal distribution of blue and green water in the Ganjiang River Basin in typical years. A variety of climate and land use scenarios were set to quantitatively analyze the effects of climate and land use changes on the blue and green water in the basin. The results show that the drought year, wet year, and normal year were 1972,1998, and 2014, respectively. The blue water content was the most abundant in the wet year, which was 2.01 times that in the dry year, while the change of the green water content was relatively stable. The green water coefficient was the highest in the dry year, which was 1.44 times that in the wet year. The change of land use had little effect on the spatial and temporal distribution of blue and green water. Under the climate change scenario, the blue and green water contents increased by 75.52.mm and 30.65.mm, respectively, and the green water coefficient decreased by 2.33%, while change trend of the blue and green water under the common change scenario was roughly the same as that under the climate change scenario, indicating that the climate change had a greater impact on the blue and green water in the basin.