In order to determine an appropriate water delivery strategy, achieve the rapid rise of the groundwater level in the lower reaches of the Tarim River, and improve the resilience of the ecosystem, this paper uses the GMS software to construct a dynamic simulation model of groundwater in the lower reaches of the Tarim River and simulates and predicts the spatiotemporal response characteristics of groundwater to single-stage, two-stage, and multi-stage water delivery scenarios. The results show that the formulation of a water delivery strategy requires that the annual water delivery volume is greater than the effective water volume. When the total amount of water delivery is constant, extending the water delivery time and expanding the water delivery interval are conducive to the rapid rise of the groundwater level. The best water delivery strategy is to transport 45 million m³ of water in two stages, with January and March to November as the water conveyance periods. The groundwater depth and water level variation are symmetrically distributed along the river channel. The groundwater depth is proportional to the distance from the two sides of the river channel, and the groundwater level change and elevation are inversely proportional to the time.