Based on the theory of natural disaster risk and the physical causes of drought disaster, considering the hazard of drought, the exposure of disaster bearing body, the vulnerability of environment and the ability of drought resistance and disaster reduction, the agricultural drought disaster risk was regionalized in Hunan Province by using the regionalization method of “bottom-up”. Taking the county level administrative region as the minimum regionalization unit, 9 evaluation indexes were selected and the agricultural drought disaster risk index was constructed by analytic hierarchy process. The regional zoning method based on Givern-Newman algorithm was adopted to divide Hunan Province into 5 drought disaster risk levels and 12 distribution areas, among which partial areas of Changde City, Hengyang City and Chenzhou City showed higher risk. There are many similarities between the results and the results of drought disaster risk regionalization of rice production in Hunan Province, which verifies the rationality of regionalization results.