In order to accurately evaluate the operation safety level of water conservancy projects, the resilience theory was introduced into the safety operation management of water conservancy projects, and the evaluation indexes system of the operation safety resilience of water conservancy projects was constructed. The order relation method (G1 method) was used to obtain the independent weight of the resilience index, the decision making trial and evaluation laboratory (DEMATEL) method was used to quantify the correlation weight of the resilience index, and the game theory was used to determine the combined weight. and a cloud model-based method for assessing the operation safety resilience of water conservancy projects was proposed. This method was used to evaluate the operation safety resilience of Jiangdu Water Control Project from 2017 to 2021. The results show that the operation safty resilience of Jiangdu Water Control Project has been improved year by year and reaches a high level of resilience. The evaluation results are consistent with the actual situation, which verifies the correctness and reliability of the method.