The uneven undercutting of the riverbed and the adjustment of the intra-annual runoff distribution caused by human interventions, including upstream reservoir construction and channel dredging, have led to changes in the interactions between runoff, tide, and estuarine topography in the Pearl River Delta river network. Based on the continuous wavelet transform method, measured hydrological data and the one-dimensional hydrodynamic model of the river network were applied to comparatively analyzing the adjustment of tidal dynamic pattern in the river network before and after the changes in topography and runoff, and the nonlinear friction term in the one-dimensional Saint-Venant equation was decomposed into runoff component, runoff-tidal component, and tidal component to further quantify the contribution of each component to the adjustment of tidal dynamic pattern. The results show that, with the changes in runoff and topography,the tidal dynamics of different tidal species significantly increases in the flood season, the tidal dynamics of high-frequency tidal species decays more rapidly in the dry season, and the tidal modulation effect caused by runoff increase in the dry season offsets the tidal dynamic enhancement caused by topographic downcutting in most river channels; the contribution of the runoff-tide interaction component in the nonlinear friction term to the adjustment of tidal dynamic pattern in the upstream river network increases with the changes in runoff and topography, and the runoff-tide nonlinear action is enhanced.