Based on wetland data in 2010,2015 and 2020 extracted by high-resolution remote sensing images, exploratory spatial data analysis method and geographic detector model methods are adopted to quantitatively analyze the temporal and spatial changes and its driving factors in Guangdong-Hong Kong-Macao Greater Bay Area from 2010 to 2020. The results show that the wetland area in Guangdong-Hong Kong-Macao Greater Bay Area from 2010 to 2020 continued to decrease, among which the reduction of constructed wetlands was more obvious (305.33km²), the natural wetland decreased by 90.17km², and the transfer of wetlands to construction land and grassland was the main form of wetland loss. From 2010 to 2015, the Greater Bay Area and coastal urban belts were the main areas of the reduced wetlands, and from 2015 to 2020, the reduced wetlands hot spots were concentrated in new areas and new industrial bases. The artificial wetland changes are mainly driven by social and economic factors including GDP, fish production and output value of secondary industry, with the influence of permanent population increasing gradually. Temperature, output value of primary industry and road density also play a vital role in wetland changes, while the other factors have insignificant influence.