The infiltration curve deduction method was used to simulate the rainfall runoff of permeable brick pavement with different clogging degrees, and the infiltration-runoff model suitable for permeable bricks during the full blockage cycle were studied. The results show that the fitting effects of the four infiltration-runoff models on the runoff data of permeable bricks with different clogging degrees, from good to bad, are Horton model, Kostiakov model, Green Ampt model, and Philip model, respectively. The Horton model can better describe the rainfall runoff process of permeable brick pavement during the full clogging cycle. The clogging degree of permeable bricks and the rainfall return period will both affect the simulation effect of the four models on the infiltration-runoff process. The simulation effect of Horton model and Kostiakov model increases with the increase of clogging degree of permeable bricks, while the simulation effect of Green Ampt model and Philip model decreases with the increase of clogging degree. As the rainfall return period increases, the simulation effects of the four models on the flow process of permeable bricks during the full clogging cycle show a trend of first decreasing and then increasing. Based on the simulation results, the Horton model was modified by introducing the clogging degree and rainfall intensity, and an infiltration-runoff model suitable for permeable brick pavement with different degrees of blockage was established.