Based on the set simulation method using Latin hypercube sampling, the risk of flood and landslide disasters in the upper reaches of the Han River region was analyzed, and the comprehensive vulnerability of six disaster bearing factors was calculated using the analytic hierarchy process. The risk of flood and landslide disasters in the region was then evaluated. The results show that the correlation coefficient between the flood flow process obtained from ensemble simulation and the measured flow process is 0.66 to 0.69, and the global accuracy of landslide simulation is 0.80 to 0.95. The risk of flood disasters is relatively low in most areas, with extremely low risk areas accounting for 94.63% and high risk areas accounting for 0.18%. However, the risk of landslide disasters is high, with a proportion of 7.21% above high risk areas. More than 80% of regions have low comprehensive vulnerability levels, which are closely related to human activities. The overall risk of flood disasters is relatively low, with areas above high risk accounting for 0.1%. High risk areas of landslide disasters are concentrated in the southwest and east, and the spatial distribution of comprehensive disaster risk is relatively similar to that of landslide disasters.