A flood simulation model of Ji’nan City was constructed based on the TELEMAC-2D model, and the inundation data of a typical rainstorm of “20070718”in Ji’nan City were selected to validate the model. The results show that the error of simulated water depth is small, indicating that the constructed urban flood simulation model has high accuracy and reliability in flood simulation. The flooding evolution processes under different rainfall return periods were simulated, and the submerged depth, inundated area, and flood velocity in the study area were analyzed. The simulation results show that, with the increase of the rainfall return period, the ratio of area with water depth greater than 0.15 m to the total area also increases. For the rainfall return period of 1,5, 10,20, 50, and 100 years, the area ratios were 0.05%, 1.10%, 1.98%, 2.89%, 4.28%, and 5.15%, respectively, and the maximum flood velocities were 0.478, 1.019, 1.309, 1.494, 1.890, and 2.214 m/s, respectively. Based on the characteristics of flood inundation, engineering and non-engineering measures for urban flood prevention and drainage in Ji’nan City were proposed.