With active resource trade in Guangdong Province, the relationship between water, energy, and food consumption is complicated, which makes comprehensive resource management difficult. Therefore,it is necessary to accurately calculate resource utilization efficiency and quantify resource interaction pressure from the perspective of trade. Based on the multi-scale input-output method,this study calculated the resource intensity of water-energy-food in Guangdong Province,quantified the circulation of water-energy-food-related resource elements,and conducted a quantitative analysis of the mutual interplay of water-energy-food resource pressures from the perspective of trade. The results show that, from 2007 to 2017, the water-energy-food resource intensity in all sectors in Guangdong Province gradually decreased, and the utilization efficiency gradually increased. High water and food intensity were concentrated in resource-intensive sectors such as the water production and supply industry and agriculture, while the energy intensity was higher in sectors such as mining, electricity,and gas production and supply. Various sectors absorbed a large amount of water-energy-food resources into the Guangdong economic system, mainly from the manufacturing industry. Urban consumption and out-of-province transfers were the main final consumption outlets for water-energy-food resources.The pressure on local resource use in Guangdong Province has improved significantly because of water-energy-food resource trade circulation. Energy trade has relieved 84.33% of the pressure on local energy use,and food trade had relieved 40.13% of the pressure on food use. The water pressure relief effect of food trade was five times that of energy trade.