This article analyzes the practical problems and research needs in the protection and management of water resources in Ji-shaped bend of the Yellow River, focusing on the implementation of the “Four Principles for Water Management” policy, in response to major national needs such as sustainable utilization of water resources, green and high-quality development, and the “annihilation war” of desertification prevention and control, as well as prominent issues such as the lack of coordination in the “human-water-city-land-industry” relationship under the shortage of water resources in the region. Key technological issues such as exploring the driving mechanism of regional water demand and tapping into water-saving potential, analyzing the synergistic evolution law of multiple factors in the “Four Principles for Water Management” and the regulation threshold, determining and warning prevention and control of risks in the implementation of the “Four Principles for Water Management” were identified. An overall research framework for intelligent monitoring, evaluation, warning, and water regulation of the “Four Principles for Water Management” in Ji-shaped bend of the Yellow River was constructed, and the key technical contents of intelligent monitoring, risk assessment, and real-time warning of the “Four Principles for Water Management” were analyzed. The implementation path for the integration and optimization of key technologies for regional groundwater river lake system protection and industrial water adaptation regulation, as well as the demonstration of integrated green coordinated development of water production energy grain under rigid constraints of water resources, has been clarified, providing important scientific and technological support for promoting the green and high-quality development in Ji-shaped bend of the Yellow River and ecological civilization construction.