MIKE3 was used to build a three-dimensional hydrodynamic numerical model of the East four portals of the Pearl River, which simulated the hydrodynamic forces of the Pearl River Estuary under different wind directions in the dry season, and analyzed the influence of the north wind, northeast wind and east wind on current velocity of rising and falling tide, salinity distribution and tidal flux of the estuary. The results show that the velocity change of rising and falling tide of surface and bottom water is opposite under the action of wind. The north wind promotes the development of the vertical circulation in Humen, increases the frequency and intensity of the vertical net circulation in neap tide, and results in the increase of the saltwater intrusion distance and the vertical average salinity in Humen. The influence of the northeast wind is similar to that of the north wind, but the range is smaller, while the east wind is opposite. The north and northeast winds reduce the tide rise of the East four portals, while the east wind increases the tide rise. The variation of falling tide is not only related to the wind direction, but also to the channel trend and vertical circulation. Therefore, the response of the falling tide to the wind is different in the East four portals. The lasting effect of wind on the saltwater intrusion of Humen is greater than that of the other three.