In order to assess the ecosystem health of Sanmenxia Reservoir wetland, we construct a wetland ecosystem health assessment index system with 15 indexes, including population density, water area, wetland management level, etc. from 3 levels of pressure, state and response based on Pressure-State-Response(PSR)Model. The index weight and index membership degree were calculated by AHP and fuzzy comprehensive evaluation method. The health status of wetland ecosystem was divided into 5 grades: “health”, “sub-health”, “vulnerable”, “ill-health” and “sick”. According to the comprehensive evaluation index, the ecosystem health status of Sanmenxia Reservoir wetland was determined. The results show that the comprehensive evaluation index of ecosystem health status of Sanmenxia Reservoir wetland is 0.696 in 2017, locating in the grade of “vulnerable” and is close to the status of “sub-healthy”; Among the 3 levels of pressure, state and response, the state is the most restrictive(0.5485), the response is moderate(0.2410), the pressure is weakest(0. 2105); Among the 15 evaluation indexes, material supply, ecological environment restoration, scientific research & entertainment and stress degree of the wetland are the dominant factors affecting the ecosystem health of Sanmenxia Reservoir wetland.