Through literature analysis, the research progress of non-point source pollution load quantification and pollution control in the Yellow River Basin is summarized. The current problems in the study of non-point source pollution in the Yellow River Basin is also analyzed. That is, there are few researches on agricultural and urban non-point source pollution, few independent research and development models, single control and management measures, and insufficient research on new pollutants. In the future, the Yellow River Basin needs to increase the monitoring of basic data, strengthen data sharing among departments, and establish a non-point source pollution database. Furthermore, the mechanism of non-point source pollution needs to be explored, and the coupling models of hydrology-water quality-hydrodynamic non-point source pollution and reservoir hydrodynamic water quality suitable for the basin should be developed. Digging into the research of non-point source pollution prevention and control, a whole process integrated control mode and management system should be developed.