To improve the accuracy of flood simulation under the disturbance of human activities above and under the ground, a grid-based rainfall-runoff simulation method considering the influence of water conservancy projects and groundwater overexploitation was proposed based on the concept of regulation reservoirs. The Gridded Xinanjiang-double anthropogenic aboveground and underground regulation distributed hydrological(GXAJ-DAR)model was established by introducing surface-subsurface double regulation modules into the Grid-Xinanjiang model. The model was compared with the Xinanjiang-Haihe semi-distributed model and tested in a typical watershed of the Haihe River Basin. The results show that the simulation accuracy of GXAJ-DAR model in the Qingshui River Watershed is higher than that of Xinanjiang-Haihe semi-distributed model. The grid-based double regulation structure can intercept surface and underground runoff according to the actual location of reservoir-controlled areas and the spatial distribution of groundwater table level. The calibration result of the parameter of free water reservoir storage capacity is more reasonable in the GXAJ-DAR model. The GXAJ-DAR model can effectively improve the flood simulation accuracy of the Qingshui River Watershed.