With the implement of Chinas “three new zone”development strategy，the ecological corridor construction in the Yangtze River catches the eye of the public. The paper studies 11 provinces of the Yangtze River Economic Zone on its socioeconomic development, hydrographic environment and water ecology. Based on DPSIR model and the interactive mechanism of driving forcepressurestateimpactresponse, it selects 26 relevant indicators from 2005 to 2014 and predicts the comprehensive protection level on the water resource of the Yangtze River Economic Belt. The result shows that the Yangtze River Economic Belt is now facing considerable pressure pertaining to the protection level of water quality, water yield and water ecology and the protection level of middlestream and downstream areas exceeds that of the uptream areas.