The epidemic of new coronavirus pneumonia exposed a series of problems in the information disclosure system. Whether the center for disease control and prevention or hospitals as public institutions should disclose relevant epidemic information has aroused widespread public concern. The Regulations on Government Information Disclosure only makes principled provisions. The existing theories of “the least reserved application”, “maximum application” and “removing from the regulation” have different flaws. Although public enterprises and institutions as a whole have similarities and differences with administrative agencies, their internal subjects are not completely the same. There are certain particularities and differences between the public subject and the public purpose, so it is necessary to follow the dual paths of “entering regulations” and “removing from regulations” for information disclosure, not using a unified path. When public enterprises and institutions meet the criteria of “substantial control”, “public interest” and “weak competition” at the same time, they should follow the path of “entering regulations”, otherwise, they should follow the path of “removing from regulations”.