While intelligent science and technology is transforming human’s method of production and lifestyle thoroughly, it also puts forward new challenges to the standard of scientific demarcation. Based on the intelligent era, this paper points out that data, structure and integration should also be the new standards of scientific demarcation in the intelligent era. The rationality of the new standards is demonstrated from the formation process of scientific theory and Figuer’s five indicators of scientific demarcation. By the means of the new standards, natural science will continue to highlight the exemplary characteristics of science, social science will gradually become a precise scientific concept, and some research fields of the humanities will also become members of the science family.