The rapid development of digital economy needs to promote the digital infrastructure. After estimating the index of cities’ digital infrastructure, this paper tests the impact of digital infrastructure on the employment based on the data of enterprises. This paper finds that the digital infrastructure can significantly increase the employment creation rate and reduce the employment destruction rate, which has a positive effect on the net employment growth rate. The results based on the sub samples show that the employment creation effects are obvious in the central region, the third-tier cities and below, and non-export enterprises. Further discussion shows that the digital infrastructure improves the employment creation rate mainly by the market access, and reduces the employment destruction rate by the adjustment of enterprises and market access. Based on the main conclusions, this paper puts forward the corresponding policies.