Abstract:"Industrial convergenceindustrial collaborationindustrial Cluster” is an important path of highquality development in the Yangtze River Delta region. Firstly, based on the current situation of industrial convergence caused by the similar endowment structure, it is found that while the internal structure of the manufacturing industry is similar in the region, there are segmented industries with specialized comparative advantages. Secondly, using the research methods of new structural economics, “a new flying geese pattern” is proposed to carry out cross-regional industrial collaboration in the Yangtze River Delta region based on the dynamic advantage of factor endowment. Thirdly, empirical tests on industrial clusters are carried out by using the panel data of 27 cities from 2010 to 2019. The results show that there is an “inverted U-shaped” structure in the advanced development and the homogenization of manufacturing industry, that under the constraint of factor endowment, excessive advanced manufacturing will restrain economic growth, while homogenization is beneficial to urban economic growth, and that both economic development and manufacturing homogenization in the Yangtze River Delta urban agglomeration have spatial spillover effect, but the effect is limited by the level of informatization.