In the digital and information era with the rapid development of the Internet, the vigorous rise of intelligent media platforms makes the information flow more complex, decentralized, iterative and uncontrollable. Digital divide, information cocoon room, algorithm abuse and other phenomena have aggravated the audience’s information anxiety and its spread. Information anxiety has become a collective disease of the public in the age of intelligent media. The main reasons are that the rapid development of digital platforms leads to multi subjectivity of information, the popularity of micro short videos leads to fragmentation of information, data interconnection algorithms point to information homogeneity, and information dissemination content changes lead to less knowledge. Therefore, in promoting the construction of digital China, we should innovate and expand the positive energy guidance of mainstream media, promote the establishment of the mechanism of public opinion guidance subject, build a field space to mitigate information anxiety, and improve the public information literacy and public opinion identification to meet the challenges brought by public information anxiety.