China ’s transnational trade has entered a new stage of two-way internationalization. The realization of two-way internationalization and coordinated development has become an inherent requirement for building a new development pattern of “double cycle”. In this context, it has great significance to test the level of coordinated development of two-way internationalization between China and different countries and regions, and to analyze the characteristics of two-way internationalization development in order to build a high-quality “double cycle”. Using the coupling coordination degree evaluation model, this study examines the synergy of the two-way internationalization data with 74 countries and regions from 2011 to 2021 and determines the dominant type of China’s two-way internationalization in each region. The results show that:first, the overall synergy level of China ’s two-way internationalization has steadily developed, maintaining a stable upward trend with Asia, while the two-way synergy with Oceania and Africa has slightly decreased. Second, the overall synergy and regional imbalance of two-way internationalization in China are relatively prominent, with the highest coupling degree of two-way internationalization in China reaching a maximum of 724.26 and a minimum of 16.71. The reason for this imbalance lies in the large disparity between the host country and the home country in the ability to carry out transnational trade. Third, China’s two-way internationalization coordinated development has shown a pattern of “rising in the east and falling in the west”, and the level of coordination with the Asian region has gradually surpassed that of Europe and the United States. However, due to the long time and large base of two-way investment between China and European and American countries, the level of two-way coordination is still at a high level even though it has experienced a slight decline in recent years. Based on the above conclusions, it is recommended that China should take the “ double cycle” new development pattern as an opportunity to promote two-way internationalization and high-quality synergy, develop a differentiated strategy for two-way internationalization development in time and place with overall coordination as the goal, rely on the regional economic cooperation platform to achieve the complementary advantages of China and foreign countries, to stimulate the synergy effect of two-way internationalization with the core of strengthening interaction, and reduce the risk of multinational operations by means of risk detection.